aCGH / CNV / SNP analysis

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Array Comparative Genomic Hybridization (aCGH) is a powerful technique used to identify and characterize DNA copy number variations across the genome.The LAGA offers a full service option for commercial aCGH arrays from Agilent and NimbleGen. Both of these platforms offer the flexibility of custom array design and multiplex formats for cost reduction. Researchers can choose to profile the entire genome with high definition probes or zoom in with fine-tiling probes to investigate aberrations and map breakpoints in any genomic location. We provide consultations for experimental design, and a full analysis service is available.

Agilent aCGH microarrays - catalog & custom designs available

Researchers can benefit from Agilent's accurate, sensitive and well-validated platform for interrogating genomic aberrations. Agilent's eArray software provides easy design of high density custom arrays from their catalog of high definition probes or with probe sequences of your choice.

Sample Requirements: 0.5 to 3ug gDNA, 250ng-1.5ug gDNA derived from fresh frozen or FFPE sample.

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Roche NimbleGen aCGH Microarrays - catalog & custom designs available

Researchers can choose the NimbleGen platform for very high density coverage. With their HD2 Catalog Tiling Arrays, one can profile the entire genome with a median spacing of 1169 bp, or one can design an custom array to fine-tile genomic regions of interest with up to 2.1 million features per array of ultra high density long oligo probes. Lower density multiplex formats are also available.

Sample Requirements: 1-2ug genomic DNA

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Illumina - SNP Discovery and Genotyping

SNP discovery is at the heart of large world-wide collaborative studies like the HapMap Project and the 1000 Genomes Project, which aim to comprehensively catalog human genetic variation. The data generated by these cutting-edge studies is an important source of content for Illumina's broad portfolio of whole-genome genotyping BeadArray products. >>Learn More